When must the Board be notified regarding significant loss of prescription drugs?

The requirement to notify the Board regarding a significant loss of prescription drugs immediately is rooted in the need to ensure patient safety and maintain the integrity of the pharmaceutical supply chain. This immediate reporting allows for swift investigation and action to prevent further loss or potential diversion of controlled substances.

Significant losses can indicate underlying issues, such as theft or mishandling, that could adversely affect public health and safety. By requiring immediate notification, regulatory bodies can initiate investigations and coordinate with law enforcement if necessary, ensuring that proper protocols are followed to protect the community and address any potential criminal activities.

The other options suggest less urgency or conditional reporting, which would not adequately address the potential risks associated with significant losses of pharmaceuticals. This immediacy emphasizes the seriousness of the responsibility that pharmacies and healthcare providers have in tracking and safeguarding controlled substances.