Which item can NOT be changed on a CII prescription?

The prescriber's DEA number is a critical piece of information on a CII (Schedule II) prescription. It is a unique identifier that the Drug Enforcement Administration assigns to medical professionals authorized to prescribe controlled substances. Any change to this number could indicate potential issues, such as a new prescriber being involved or possible fraudulent activities. Therefore, altering the DEA number on a prescription would not be permissible, as it is integral to verifying the legitimacy of the prescription itself and ensuring compliance with legal regulations governing controlled substances.

In contrast, aspects such as a patient's address, dosage form, and drug quantity can be amended with appropriate documentation or a new prescription issued by the prescriber, as long as these changes maintain the integrity and intent of the original prescription.